[Influence of biphosphonates on the integration process of endosseous implants evaluated using single photon emission computerized tomography (SPECT)].
Identifieur interne : 007B83 ( Main/Exploration ); précédent : 007B82; suivant : 007B84[Influence of biphosphonates on the integration process of endosseous implants evaluated using single photon emission computerized tomography (SPECT)].
Auteurs : F. Bambini [Italie] ; C A De Stefano ; L. Giannetti ; L. Memè ; M. PellecchiaSource :
- Minerva stomatologica [ 0026-4970 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte, Alendronate (administration et posologie), Alendronate (pharmacologie), Alendronate (usage thérapeutique), Cicatrisation de plaie, Femelle, Humains, Molaire (), Mâchoire partiellement édentée (), Mâchoire partiellement édentée (imagerie diagnostique), Ostéo-intégration (), Pose d'implant dentaire endo-osseux, Prémolaire (), Tomographie par émission monophotonique, Évaluation de médicament.
- MESH :
- administration et posologie : Alendronate.
- imagerie diagnostique : Mâchoire partiellement édentée.
- pharmacologie : Alendronate.
- usage thérapeutique : Alendronate.
- Adulte, Cicatrisation de plaie, Femelle, Humains, Molaire, Mâchoire partiellement édentée, Ostéo-intégration, Pose d'implant dentaire endo-osseux, Prémolaire, Tomographie par émission monophotonique, Évaluation de médicament.
English descriptors
- KwdEn :
- Adult, Alendronate (administration & dosage), Alendronate (pharmacology), Alendronate (therapeutic use), Bicuspid (surgery), Dental Implantation, Endosseous, Drug Evaluation, Female, Humans, Jaw, Edentulous, Partially (diagnostic imaging), Jaw, Edentulous, Partially (surgery), Molar (surgery), Osseointegration (drug effects), Tomography, Emission-Computed, Single-Photon, Wound Healing.
- MESH :
- chemical , administration & dosage : Alendronate.
- chemical , pharmacology : Alendronate.
- chemical , therapeutic use : Alendronate.
- diagnostic imaging : Jaw, Edentulous, Partially.
- drug effects : Osseointegration.
- surgery : Bicuspid, Jaw, Edentulous, Partially, Molar.
- Adult, Dental Implantation, Endosseous, Drug Evaluation, Female, Humans, Tomography, Emission-Computed, Single-Photon, Wound Healing.
Abstract
Biphosphonates are a large class of drugs which inhibits the resorbing activity of osteoclasts. The aim of this study was to evaluate the influence of topical application of the biphosphonate alendronate on the integration process of endosseus implants placed in a partially edentulous patient. After incision and elevation of a mucoperiosteal flap and carrying out the osteotomy, 2 SLA implants 10 mm long and 3.5 mm wide were inserted in the area of # 4.5 and 4.6. Before placement of # 4.5, a paste made of grinded tablets of alendronate and Rifocin was applied in the osteotomy. Fifteen days after stage I, an evaluation of the osteoblastic peri-implant activity was carried out using single photon emission computerized tomography. Healing was within normal limits. Four months after stage I, the 2 implants were uncovered and considered clinically and radiographically integrated. The osteoblastic activity was judged similar bet-ween the 2 implants in terms of quality of biological response. Osseous scintigraphy and the achievement of implant osseointegration demonstrate the lack of toxicity of the topical application of the biphosphonate alendronate during the initial osseous healing. However, new experimental studies and clinical trials are necessary to confirm the results obtained.
PubMed: 12874537
Affiliations:
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Le document en format XML
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Bambini</name><affiliation wicri:level="1"><nlm:affiliation>Cattedra di Chirurgia Speciale, Odontostomatologica, Istituto di Scienze Odontostomatologiche, Università degli Studi di Ancona, Ancona, Italy. m.pallecchia@libero.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cattedra di Chirurgia Speciale, Odontostomatologica, Istituto di Scienze Odontostomatologiche, Università degli Studi di Ancona, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="De Stefano, C A" sort="De Stefano, C A" uniqKey="De Stefano C" first="C A" last="De Stefano">C A De Stefano</name></author><author><name sortKey="Giannetti, L" sort="Giannetti, L" uniqKey="Giannetti L" first="L" last="Giannetti">L. Giannetti</name></author><author><name sortKey="Meme, L" sort="Meme, L" uniqKey="Meme L" first="L" last="Memè">L. 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Memè</name></author><author><name sortKey="Pellecchia, M" sort="Pellecchia, M" uniqKey="Pellecchia M" first="M" last="Pellecchia">M. Pellecchia</name></author></analytic><series><title level="j">Minerva stomatologica</title><idno type="ISSN">0026-4970</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Alendronate (administration & dosage)</term><term>Alendronate (pharmacology)</term><term>Alendronate (therapeutic use)</term><term>Bicuspid (surgery)</term><term>Dental Implantation, Endosseous</term><term>Drug Evaluation</term><term>Female</term><term>Humans</term><term>Jaw, Edentulous, Partially (diagnostic imaging)</term><term>Jaw, Edentulous, Partially (surgery)</term><term>Molar (surgery)</term><term>Osseointegration (drug effects)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Wound Healing</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Alendronate (administration et posologie)</term><term>Alendronate (pharmacologie)</term><term>Alendronate (usage thérapeutique)</term><term>Cicatrisation de plaie</term><term>Femelle</term><term>Humains</term><term>Molaire ()</term><term>Mâchoire partiellement édentée ()</term><term>Mâchoire partiellement édentée (imagerie diagnostique)</term><term>Ostéo-intégration ()</term><term>Pose d'implant dentaire endo-osseux</term><term>Prémolaire ()</term><term>Tomographie par émission monophotonique</term><term>Évaluation de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Alendronate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Alendronate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Alendronate</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Alendronate</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Jaw, Edentulous, Partially</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Osseointegration</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Mâchoire partiellement édentée</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Alendronate</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Bicuspid</term><term>Jaw, Edentulous, Partially</term><term>Molar</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Alendronate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Dental Implantation, Endosseous</term><term>Drug Evaluation</term><term>Female</term><term>Humans</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Wound Healing</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Cicatrisation de plaie</term><term>Femelle</term><term>Humains</term><term>Molaire</term><term>Mâchoire partiellement édentée</term><term>Ostéo-intégration</term><term>Pose d'implant dentaire endo-osseux</term><term>Prémolaire</term><term>Tomographie par émission monophotonique</term><term>Évaluation de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Biphosphonates are a large class of drugs which inhibits the resorbing activity of osteoclasts. The aim of this study was to evaluate the influence of topical application of the biphosphonate alendronate on the integration process of endosseus implants placed in a partially edentulous patient. After incision and elevation of a mucoperiosteal flap and carrying out the osteotomy, 2 SLA implants 10 mm long and 3.5 mm wide were inserted in the area of # 4.5 and 4.6. Before placement of # 4.5, a paste made of grinded tablets of alendronate and Rifocin was applied in the osteotomy. Fifteen days after stage I, an evaluation of the osteoblastic peri-implant activity was carried out using single photon emission computerized tomography. Healing was within normal limits. Four months after stage I, the 2 implants were uncovered and considered clinically and radiographically integrated. The osteoblastic activity was judged similar bet-ween the 2 implants in terms of quality of biological response. Osseous scintigraphy and the achievement of implant osseointegration demonstrate the lack of toxicity of the topical application of the biphosphonate alendronate during the initial osseous healing. However, new experimental studies and clinical trials are necessary to confirm the results obtained.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="De Stefano, C A" sort="De Stefano, C A" uniqKey="De Stefano C" first="C A" last="De Stefano">C A De Stefano</name><name sortKey="Giannetti, L" sort="Giannetti, L" uniqKey="Giannetti L" first="L" last="Giannetti">L. Giannetti</name><name sortKey="Meme, L" sort="Meme, L" uniqKey="Meme L" first="L" last="Memè">L. Memè</name><name sortKey="Pellecchia, M" sort="Pellecchia, M" uniqKey="Pellecchia M" first="M" last="Pellecchia">M. Pellecchia</name></noCountry><country name="Italie"><noRegion><name sortKey="Bambini, F" sort="Bambini, F" uniqKey="Bambini F" first="F" last="Bambini">F. 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